Risk Factors Associated with Early and Late-onset of Neonatal Sepsis in Duhok City


  • Delshad Abdallah Mohamed Department of Nursing , College of Nursing, University of Duhok, Duhok, Iraq
  • Salah Abdulkareem Ibrahim Department of Pediatric , College of Medicine, University of Duhok, Duhok, Iraq
  • Sherzad Khudeida Suleman Community Health and Pediatric Unit, College of Nursing, University of Duhok, Duhok, Iraq




Early Onset of Neonatal Sepsis, Late-Onset of Neonatal Sepsis, Risk Factors


Backgrounds and objectives: Neonatal sepsis refers to bacterial, fungal, protozoan infections or any viral agents or pathogens which inter to the newborns bloodstream after the birth. Neonatal Sepsis is the main reason of deaths in non-developed countries. There is an overall prevalence of 54.67% in Iraq. The present study intends to explore the demographic and clinical affecting factors of early and late onset of neonatal sepsis of a sample population in Duhok city. The predictors of neonatal sepsis diagnosis were determined accordingly.
Methods: This cross-sectional study shows 110 neonates who were diagnosed with early or late onset of neonatal sepsis. A paediatrician diagnosed the patients through physical and clinical assessment.
Results: The prevalence of early and late onset of neonatal sepsis was 52.73% and 47.7%, respectively. The Apgar scores of less than seven and more than seven were risk factors for early and late-onset of neonatal sepsis, prolonged rupture of the membranes greater than18 hours and multiple gestations are common in patients with early onset of neonatal sepsis.
Conclusions: The study showed that the early onset of neonatal sepsis or late-onset of neonatal sepsis was associated with Apgar score and prolonged rupture of the membranes.


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[1] Rosdahl CB, Kowalski MT. Textbook of basic nursing: Lippincott Williams & Wilkins; 2008.
[2] Thacker N. Improving status of neonatal health in India. Indian acad pediatrics maulana azad medical college, dept pediatrics, New Delhi, 110 002, India; 2007.
[4] Say L, Chou D, Gemmill A, Tunçalp Ö, Moller A-B, Daniels J, et al. Global causes of maternal death: a WHO systematic analysis. The Lancet Global Health. 2(6):P: e323-e33. 2014.
[6] Black RE, Laxminarayan R, Temmerman M, Walker N. Reproductive maternal newborn and child health. Disease control priorities. Volume 2.P. 2016.
[.] Yoon HS, Shin YJ, Ki M. Risk factors for neonatal infections in full-term babies in South Korea. Yonsei medical journal. 49(4):P: 530-6. 2008.
[4] Kulkarni M. Manual of Neonatology. Jaypee Brothers.P. 2000.
[2] Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. The Lancet Respiratory Medicine. 6(3):P: 223-30. 2018.
[5] Al-Mayah QS, Chalob FA, Jawad TI. Incidence of neonatal sepsis in a sample of Iraqi newborns. Pak J Biotechnol. 14(4):P: 797-802 2017.
[2] Atrushi AM. The profile of neonatal sepsis in Duhok city and predictors of mortality: A prospective case series study. Duhok Medi-cal Journal. 12(2):P: 10-20. 2018.
[30] Shaker NZ. Disease Patterns and outcomes of Neonatal Admissions at Raparin Pediatric Teaching Hospital in Erbil City. nursing national Iraqi speciality. 28(2):P: 39-46. 2015.
[33] Haque KN. Definitions of bloodstream infection in the newborn. Pediatric Critical care medicine. 6(3):P: S45-S9. 2005.
[37] Finster M, Wood M. The Apgar score has survived the test of time. The Journal of the American Society of Anesthesiologists. 102(4):P: 855-7. 2005.
[34] de Waal K, Kluckow M. Prolonged rupture of membranes and pulmonary hypoplasia in very preterm infants: pathophysiology and guided treatment. The Journal of pediatrics. 166(5):P: 1113-20. 2015.
[14] Chacko B, Sohi I. Early onset neonatal sepsis. The Indian Journal of Pediatrics. 72(1):P: 23. 2005.
[15] Network N. National Neonatal-Perinatal Database (Report 2002–2003). New Delhi, India: Department of Pediatrics, All India Institute of Medical Sciences.P. 2005.
[16] Siakwa M, Kpikpitse D, Mupepi SC, Semuatu M. Neonatal sepsis in rural Ghana: A case-control study of risk factors in a birth cohort.P. 2014.
[17] Adatara P, Afaya A, Salia SM, Afaya RA, Konlan KD, Agyabeng-Fandoh E, et al. Risk Factors Associated with Neonatal Sepsis: A Case Study at a Specialist Hospital in Ghana. The Scientific World Journal. 2019:P. 2019.
[35] Park K. Innate immunity in allergen-induced airway inflammation Role of macrophage migration inhibitory factor (MIF) and cholesterol 25-hydroxylase (CH25H) in alveolar macrophages: The Johns Hopkins University; 2011.
[32] Hasan M, Mahmood C. Predictive values of risk factors in neonatal sepsis. Journal of Bangladesh College of Physicians and Surgeons. 29(4):P: 187-95. 2012.
[70] Siakwa M, Kpikpitse MD, Mohamed S. Neonatal sepsis in rural Ghana: A case control study of risk factors in a birth cohort. IJRMHS & KAJ. 4(5):P: 77-88. 2014.
[73] Freeman MC, Stocks ME, Cumming O, Jeandron A, Higgins JP, Wolf J, et al. Systematic review: hygiene and health: systematic review of handwashing practices worldwide and update of health effects. Tropical Medicine & International Health. 19(8):P: 906-16. 2014.
[77] Nili F, Nayeri F, Shariat M. Risk factors in early onset neonatal sepsis.P. 2006.
[74] Shah G, Budhathoki S, Das B, Mandal R. Risk factors in early neonatal sepsis. Kath-mandu University medical journal (KUMJ). 4(2):P: 187-91. 2006.
[76] Soman M, Green B, Daling J. Risk factors for early neonatal sepsis. American journal of epidemiology. 121(5):P: 712-9. 1985.
[7.] Cloherty JP, Eichenwald EC, Stark AR. Manual of neonatal care: Lippincott Williams & Wilkins; 2008.
[74] Bouman A, Schipper M, Heineman MJ, Faas MM. Gender difference in the non-specific and specific immune response in humans. American Journal of Reproductive Immunology. 52(1):P: 19-26. 2004.
[27] Marshall JE, Raynor MD. Myles' Textbook for Midwives E-Book: Elsevier Health Sciences; 2014.
[28] Alam MM, Saleem AF, Shaikh AS, Munir O, Qadir M. Neonatal sepsis following pro-longed rupture of membranes in a tertiary care hospital in Karachi, Pakistan. The Journal of Infection in Developing Countries. 8(01):P: 067-73. 2014.
[29] Kayange N, Kamugisha E, Mwizamholya DL, Jeremiah S, Mshana SE. Predictors of positive blood culture and deaths among neonates with suspected neonatal sepsis in a tertiary hospital, Mwanza-Tanzania. BMC pediatrics. 10(1):P: 39. 2010.
[30] Polinski C. The value of the white blood cell count and differential in the prediction of neonatal sepsis. Neonatal network: NN. 15(7):P: 13-23. 1996.




How to Cite

Mohamed DA, Ibrahim SA, Suleman SK. Risk Factors Associated with Early and Late-onset of Neonatal Sepsis in Duhok City. Erbil j. nurs. midwifery [Internet]. 2020 May 30 [cited 2024 Jun. 18];3(1):1-10. Available from: https://ejnm.hmu.edu.krd/index.php/ejnm/article/view/74



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