Association of Rhesus Blood Group (RhD) and Toxoplasmosis in Women with Miscarriage in Erbil

Authors

  • Banaz Sadik Smael Department of Nursing, College of Nursing, Hawler Medical University
  • Sadiya Abdulla Palpitany Department of Nursing, College of Nursing, Hawler Medical University
  • Kazhal Hassan Hama Rahim Department of Nursing, College of Nursing, Hawler Medical University

DOI:

https://doi.org/10.15218/ejnm.2018.12

Keywords:

Toxoplasmosis, Rh factor, ABO blood group

Abstract

Background and objective: Toxoplasmosis has worldwide distribution and the incidence of the disease varies around the world. Human blood is categorized within two main systems: ABO and Rhesus factor blood group systems. The Rhesus factor protein which is the Rhesus factor gene product and a major component in the Rh blood group system carries the strongest blood group immunogen, This study aimed to estimate the sero-prevalence of toxoplasmosis and to investigate the distribution of ABO and Rhesus factor blood groups among women with toxoplasma infection. Methods: This cross-sectional study was carried out in Erbil from September 2017 to April 2018, in which 200 women with history of abortion were enrolled. Blood samples were collected and tested for anti-toxoplasma IgM antibody using direct agglutination and enzyme linked immunosorbent assay techniques. Results: the percentages of anti-toxoplasma IgM was 33.5% .and 65 (97%) of the seropositive women were RhD negative. Significant relationship between RhD blood group and Toxoplasma seropositive was observed while no significant relationship was found between toxoplasmosis and each ABO phenotype and demographic characteristics. Comparably, high sero-prevalence rate of anti-toxoplasma antibody was found among age group 21-40 years old (73.1%), however, it was statistically non- significant. Conclusion: Anti toxoplasma IgM antibodies was relatively high among women with history of abortion in Erbil and Rhesus factor positive was significant.

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References

[1] Dubey JP, Lindsay DS, Speer CA . Structures of Toxoplasma gondii tachyzoites, bradyzoites and Sporozoites and biology and development of. tissue cysts. Clinical Microbiology Review 1998.( 11):267-299. [2] Hill DE, Chirukandoth S and Dubey JP . Biology and epidemiology of Toxoplasma gondii in man and animals. Animal Health Research Review, 2005 (6):41-61. [3] Dubey JP . Toxoplasmosis of animals and humans. Second edition .Boca .Raton, Florida CRC press. [4] Dawson D . Foodborne protozoan parasites. Internal Journal of Food Microbiology. 2005 (103):207- 227. [5] Walker M and Zunt JR .Parasitic central nervous system infections in immunocompromised hosts. Clinical iInfectious Disease. 2005. (40):1005-1015. [6] Balasundaram MB, Andavar R, Palaniswamy M , Venkatapathy N. outbreak of acquired ocular toxoplasmosis involving 248 patients. Archive of Ophthalmology, 2010(128):28-32. [7] Flegel W.A. Molecular genetics of RH and its clinical application. Transfusion Clinical Biology 2006 (13): 4–12.
[8] Carritt B., Kemp T.J., Poulter M. Evolution of the human RH (rhesus) blood group genes: a 50 year old prediction (partially) fulfilled. Human Molecular Genetic. 1997 (6): 843–850.
[9] Biver S., Scohy S., Szpirer J., Szpirer C., Andre B., Marini A.M. Physiological role of the putative ammonium transporter RhCG in the mouse. Transfusion Clinical Biology. 2006 ,(13): 167–168.
[10] Kustu S., Inwood W. Biological gas channels for NH3 and CO2: evidence that Rh (Rhesus) proteins are CO2 channels. Transfusion Clinical Biology. 2006, (13): 103–110.
[11] Novotná M., Havlíček J., Smith A.P., Kolbeková P., Skallová A., Klose J.et al Toxoplasma and reaction time: role of toxoplasmosis in the origin, preservation and geographical distribution of Rh blood group polymorphism. Parasitology. 2008, (135): 1253–1261.
[12] Flegr J., Klose J., Novotná M., Berenreitterová M., Havlíče J. Increased incidence of traffic accidents in Toxoplasma infected military drivers and protective effect RhD molecule revealed by a large-scale prospective cohort study. BMC Infectious Disease. 2009. (9): e72.
[13] Kader JM, Seroprevalence of Toxoplasma gondi in some meat producing animals in Erbil city. MSc thesis. College of Medicine. Hawler Medical University. 2010.
[14] Bakre HM, Evaluation of immunocapture ELISA and other testes for diagnosing Toxoplasmosis. MSc thesis. College of Medicine. Hawler Medical University. 2002.
[15] Mohammed AK, Possible role of Toxoplasma gondi infection, cytokines and inflammatory markers in patients with major depressive disorders. MSc thesis. College of Medicine. Hawler Medical University. 2015.
[16] Kolbekova P, Kourbatova E, Novotna M, Kodym P, Flegr J. New and old riskfactors for Toxoplasma gondii infection: prospective cross-sectional study among military personnel in the Czech Republic. Clinical Microbiology Infection. 2007;13 (10):12-7. [17] Midtvedt T, Vaage L. Relationship between Toxoplasma gondii antibodies and blood group. European Journal of Clinical Microbiology Infectious Disease. 1989;8 (6):575-6. [18] Gill HS. Occurrence of Toxoplasma gondii antibodies in Tanzanian blood donors. East African Medical Journal. 1985;62 (8):585-8. [19] Lecolier B, Grynberg H, Freund M. Absence of relationship between Toxoplasma gondii antibodies and blood group in pregnant women in France. European Journal of Clinical Microbiology Infectious Disease. 1990;9(2):152-3. [20] Al-Jebouri M, Al-Janabi M, Ismail H. The prevalence of Toxoplasmosis among female patient in Al-Hawija and Al- Baiji Districts in Iraq. Open Journal of Epidemiology.2013;3(38):85-88.
[21] Hadi HS, Kadhim RA, Al-Mammori RT. Seroepidemiological aspects for Toxoplasma gondii infection in women of qadisyiyah province, Iraq. International Journal of Pharmacology and Technelogy Research.2016;9(11):252-59.
[22] Hung CC, Fan CK, Su KE, Sung FC, Chiou AY, Gil V, et al. Serological screening and toxoplasmosis exposure factors among pregnant women in the Democratis Republic of Sao Tome and Principe. Journal of Transactions of the Royal Society Tropical Medical Hygiene. 2007; 101 (2):97-103.
[23] Jones JL, Kruszan MD, Wilson M, Mcquillan G, Navin T, McAuley JB. Toxoplasma gondii Infection in the United states: seroprevalence and risk factors. American Journal of Epidemiology. 2001 154 (4):357-65.
[24] Ahmed D, Shahabeddin S, Mohsen A, Azadeh M, Ehsan A, Azar S, et al Seroprevalence of Toxoplasma gondii in the Iranian general population: A systematic review and meta-analysis ,Acta Tropica. 2014; (137):185-194 .
[25] Parnell L L. Examination of Possible Protective Effect of Rhesus D Positive Blood Factor on Toxoplasma-related Depressive Symptoms in Pregnancy. PhD. College of Nursing University of South Florida. 2014.

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Published

2018-11-30

How to Cite

1.
Smael BS, Palpitany SA, Hama Rahim KH. Association of Rhesus Blood Group (RhD) and Toxoplasmosis in Women with Miscarriage in Erbil. Erbil j. nurs. midwifery [Internet]. 2018 Nov. 30 [cited 2024 Apr. 25];1(2):94-100. Available from: https://ejnm.hmu.edu.krd/index.php/ejnm/article/view/37

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