Association of Liver Function Tests and Inflammatory Biomarkers with eGFR in Chronic Kidney Disease Patients on Hemodialysis in Erbil City
DOI:
https://doi.org/10.15218/ejnm.2026.01Keywords:
Chronic Kidney Disease, Estimated Glomerular Filtration Rate, Lipid ProfileAbstract
Background and Objective: Chronic Kidney Disease is a global public health concern, particularly in patients undergoing hemodialysis, who face elevated cardiovascular risks and progressive renal dysfunction. These patients often exhibit disrupted lipid metabolism, impaired glycemic control, and altered body composition. However, the sex-specific associations between these metabolic factors and kidney function remain unclear. This study aimed to evaluate the relationship between anthropometric measurements, glycemic markers, and lipid profile components. It estimated the Glomerular Filtration Rate (eGFR) in male and female Chronic Kidney Disease patients on maintenance hemodialysis in Erbil City.
Methods: A cross-sectional study was conducted at Erbil Teaching Hospital between November 2024 and April 2025. It included 70 adult patients with Chronic Kidney Disease undergoing regular hemodialysis and 70 healthy controls. Body mass index (BMI), glycemic markers (fasting blood sugar and HbA1c), lipid profiles (total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, and very-low-density lipoprotein), and eGFR (calculated using the 2021 CKD-EPI formula) were analyzed. Correlation analyses were performed separately for genders using GraphPad Prism.
Results: BMI showed a statistically significant but clinically weak negative relationship with eGFR in both men and women. Glycemic markers (blood sugar and HbA1c) were inversely correlated with eGFR in males, whereas in females they showed a positive correlation, possibly reflecting early hyperfiltration. TC was weakly positively associated with eGFR in males but not in females. HDL showed a strong positive correlation with eGFR in males only. LDL was marginally positively associated with eGFR in females, while TG and VLDL showed no significant correlation in either sex.
Conclusion: In individuals undergoing hemodialysis, metabolic indicators exhibited sex-specific correlations with eGFR levels. Glycemic parameters and HDL had a stronger correlation with eGFR than BMI and other lipid indices. These findings emphasize the significance of sex-specific assessment in the metabolic management of chronic renal disease patients.
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Copyright (c) 2026 Jwan Qader Azeez, Dler Qader Gallaly, Ismail Mustafa Maulood (Author)
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