Effect of Serum Lipid Profile and Renal Functions during Pregnancy and its associated diseases in Sulaimanyah / Kurdistan Region
DOI:
https://doi.org/10.15218/ejnm.2025.03Keywords:
Renal Function, Pregnancy, Estimated Glomerular Filtration Rate, Serum Lipid ProfileAbstract
Background and Objective: The physiological function of the kidneys poses significant challenges during pregnancy, impacting maternal and fetal health. Understanding the interplay between renal functions and serum lipid profiles is crucial for managing maternal health. This study aims to investigate serum lipid profiles and their association with renal function in pregnancy and compare them with non-pregnant status. The objective of this study was to conduct a prospective analysis of blood lipid concentration, namely lipoprotein, as well as the rates of urea and creatinine, in pregnant women, and thereafter compare these measurements with those of non-pregnant women.
Methods: A case- control study was conducted on pregnant women in Sulaimanyah/Kurdistan. Both serum lipid profile tests, including triglycerides, cholesterol, and lipoprotein levels, and renal function markers, such as serum creatinine, urea, and estimated glomerular filtration rate, were measured at various stages of pregnancy. Data was analyzed by the Statistical Package for the Social Sciences version 22.0 to identify correlations between serum lipid profile, renal function, and pregnancy outcomes.
Results: This study highlights significant positive correlations of low-density lipoprotein with gestation age, cholesterol, triglyceride, and high-density lipoprotein, alongside strong negative correlations with total serum bilirubin and creatinine in pregnancy. This correlation was not found in non-pregnant status. Additionally, estimated glomerular filtration rate exhibits strong positive correlations with cholesterol and low-density lipoprotein and negative correlations with total serum bilirubin and creatinine.In non-pregnant individuals, estimated glomerular filtration rate moderately correlates with random blood sugar while strongly correlating negatively with urea and creatinine.Mean ± Standard deviation of urea and creatinine were significantly higher in non-pregnant women while cholesterol and estimated glomerular filtration rate were significantly high among pregnant women.
Conclusion: This study highlighted notable metabolic disparities between pregnant and non-pregnant women, particularly in terms of lipid profiles and renal function.
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Copyright (c) 2025 Azad Mohammed Aziz Ahmed, Amjad Mahmood Qadir, Jamal Kareem Shakor , Musa M. Zorab (Author)
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